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"We cannot change the cards we are dealt, just how we play the hand."
--Randy Pausch

A lot of professors give talks titled "The Last Lecture." Professors are asked to consider their demise and to ruminate on what matters most to them. And while they speak, audiences can't help but mull the same question: What wisdom would we impart to the world if we knew it was our last chance? If we had to vanish tomorrow, what would we want as our legacy?

When Randy Pausch, a computer science professor at Carnegie Mellon, was asked to give such a lecture, he didn't have to imagine it as his last, since he had recently been diagnosed with terminal cancer. But the lecture he gave--"Really Achieving Your Childhood Dreams"--wasn't about dying. It was about the importance of overcoming obstacles, of enabling the dreams of others, of seizing every moment (because "time is all you have...and you may find one day that you have less than you think"). It was a summation of everything Randy had come to believe. It was about living.

In this book, Randy Pausch has combined the humor, inspiration and intelligence that made his lecture such a phenomenon and given it an indelible form. It is a book that will be shared for generations to come.

Questions for Randy Pausch

We were shy about barging in on Randy Pausch's valuable time to ask him a few questions about his expansion of his famous Last Lecture into the book by the same name, but he was gracious enough to take a moment to answer. (See Randy to the right with his kids, Dylan, Logan, and Chloe.) As anyone who has watched the lecture or read the book will understand, the really crucial question is the last one, and we weren't surprised to learn that the "secret" to winning giant stuffed animals on the midway, like most anything else, is sheer persistence.

Amazon.com: I apologize for asking a question you must get far more often than you'd like, but how are you feeling?

Pausch: The tumors are not yet large enough to affect my health, so all the problems are related to the chemotherapy. I have neuropathy (numbness in fingers and toes), and varying degrees of GI discomfort, mild nausea, and fatigue. Occasionally I have an unusually bad reaction to a chemo infusion (last week, I spiked a 103 fever), but all of this is a small price to pay for walkin' around.

Amazon.com: Your lecture at Carnegie Mellon has reached millions of people, but even with the short time you apparently have, you wanted to write a book. What did you want to say in a book that you weren't able to say in the lecture?

Pausch: Well, the lecture was written quickly--in under a week. And it was time-limited. I had a great six-hour lecture I could give, but I suspect it would have been less popular at that length ;-).

A book allows me to cover many, many more stories from my life and the attendant lessons I hope my kids can take from them. Also, much of my lecture at Carnegie Mellon focused on the professional side of my life--my students, colleagues and career. The book is a far more personal look at my childhood dreams and all the lessons I've learned. Putting words on paper, I've found, was a better way for me to share all the yearnings I have regarding my wife, children and other loved ones. I knew I couldn't have gone into those subjects on stage without getting emotional.

Amazon.com: You talk about the importance--and the possibility!--of following your childhood dreams, and of keeping that childlike sense of wonder. But are there things you didn't learn until you were a grownup that helped you do that?

Pausch: That's a great question. I think the most important thing I learned as I grew older was that you can't get anywhere without help. That means people have to want to help you, and that begs the question: What kind of person do other people seem to want to help? That strikes me as a pretty good operational answer to the existential question: "What kind of person should you try to be?"

Amazon.com: One of the things that struck me most about your talk was how many other people you talked about. You made me want to meet them and work with them--and believe me, I wouldn't make much of a computer scientist. Do you think the people you've brought together will be your legacy as well?

Pausch: Like any teacher, my students are my biggest professional legacy. I'd like to think that the people I've crossed paths with have learned something from me, and I know I learned a great deal from them, for which I am very grateful. Certainly, I've dedicated a lot of my teaching to helping young folks realize how they need to be able to work with other people--especially other people who are very different from themselves.

Amazon.com: And last, the most important question: What's the secret for knocking down those milk bottles on the midway?

Pausch: Two-part answer:
1) long arms
2) discretionary income / persistence

Actually, I was never good at the milk bottles. I'm more of a ring toss and softball-in-milk-can guy, myself. More seriously, though, most people try these games once, don't win immediately, and then give up. I've won *lots* of midway stuffed animals, but I don't ever recall winning one on the very first try. Nor did I expect to. That's why I think midway games are a great metaphor for life.

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Neil Campbell and Jane Reece's BIOLOGYremains unsurpassed as the most successful majors biology textbook in the world. This text has invited more than 4 million students into the study of this dynamic and essential discipline.The authors have restructured each chapter around a conceptual framework of five or six big ideas. An Overview draws students in and sets the stage for the rest of the chapter, each numbered Concept Head announces the beginning of a new concept, and Concept Check questions at the end of each chapter encourage students to assess their mastery of a given concept. New Inquiry Figures focus students on the experimental process, and new Research Method Figures illustrate important techniques in biology. Each chapter ends with a Scientific Inquiry Question that asks students to apply scientific investigation skills to the content of the chapter.

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A brain scientist's journey from a debilitating stroke to full recovery becomes an inspiring exploration of human consciousness and its possibilities

On the morning of December 10, 1996, Jill Bolte Taylor, a thirty-seven-year-old Harvard-trained brain scientist, experienced a massive stroke when a blood vessel exploded in the left side of her brain. A neuroanatomist by profession, she observed her own mind completely deteriorate to the point that she could not walk, talk, read, write, or recall any of her life, all within the space of four brief hours. As the damaged left side of her brain--the rational, grounded, detail- and time-oriented side--swung in and out of function, Taylor alternated between two distinct and opposite realties: the euphoric nirvana of the intuitive and kinesthetic right brain, in which she felt a sense of complete well-being and peace; and the logical, sequential left brain, which recognized Jill was having a stroke, and enabled her to seek help before she was lost completely.

In My Stroke of Insight, Taylor shares her unique perspective on the brain and its capacity for recovery, and the sense of omniscient understanding she gained from this unusual and inspiring voyage out of the abyss of a wounded brain. It would take eight years for Taylor to heal completely. Because of her knowledge of how the brain works, her respect for the cells composing her human form, and most of all an amazing mother, Taylor completely repaired her mind and recalibrated her understanding of the world according to the insights gained from her right brain that morning of December 10th.

Today Taylor is convinced that the stroke was the best thing that could have happened to her. It has taught her that the feeling of nirvana is never more than a mere thought away. By stepping to the right of our left brains, we can all uncover the feelings of well-being and peace that are so often sidelined by our own brain chatter. A fascinating journey into the mechanics of the human mind, My Stroke of Insight is both a valuable recovery guide for anyone touched by a brain injury, and an emotionally stirring testimony that deep internal peace truly is accessible to anyone, at any time.

Questions for Jill Bolte Taylor

Amazon.com: Your first reaction when you realized what was happening to your body was one you would expect: "Oh my gosh, I'm having a stroke!" Your second, though, was a little more surprising: "Wow, this is so cool!" What could be cool about a stroke?

Taylor: I grew up to study the brain because I have a brother who is only 18 months older than I am. He was very different in the way he perceived experiences and then chose to behave. As a result, I became fascinated with the human brain and how it creates our perception of reality. He was eventually diagnosed with the brain disorder schizophrenia, and I dedicated my career to the postmortem investigation of the human brain in an attempt to understand, at a biological level, what are the differences between my brain and my brother's brain. On the morning of the stroke, I realized that my brain was no longer functioning like a "normal" brain and this insight into my brother's reality excited me. I was fascinated to intimately understand what it might be like on the inside for someone who would not be diagnosed as normal. Through the eyes of a curious scientist, this was an absolutely rare and fascinating experience for me to witness the breakdown of my own mind.

Amazon.com: What did you learn about the brain from your stroke and your recovery that your scientific training hadn't prepared you for?

Taylor: My scientific training did not teach me anything about the human spirit and the value of compassion. I had been trained as a scientist, not as a clinician. I can only hope that we are teaching our future physicians about compassion in medicine, and I know that some medical schools, including the Indiana University School of Medicine, have created a curriculum with this intention.

My training as a scientist, however, did provide me with a roadmap to how the body and brain work. And although I lost my left cognitive mind that thinks in language, I retained my right hemisphere that thinks in pictures. As a result, although I could not communicate with the external world, I had an intuitive understanding about what I needed to do in order to create an environment in which the cells in my brain could be happy and healthy enough that they could regain their function. In addition, because of my training, I had an innate trust in the ability of my brain to be able to recover itself and my mother and I respected the organ by listening to it. For example, when I was tired, I allowed my brain to sleep, and when I was fresh and capable of focusing my attention, we gave me age-appropriate toys and tools with which to work.

Amazon.com: Your stroke affected functions in your left brain, leaving you to what you call the "la-la land" of your right hemisphere. What was it like to live in your right brain, and then to rebuild your left?

Taylor: When the cells in my left brain became nonfunctional because they were swimming in a pool of blood, they lost their ability to inhibit the cells in my right hemisphere. In my right brain, I shifted into the consciousness of the present moment. I was in the right here, right now awareness, with no memories of my past and no perception of the future. The beauty of La-la land (my right hemisphere experience of the present moment) was that everything was an explosion of magnificent stimulation and I dwelled in a space of euphoria. This is great way to exist if you don't have to communicate with the external world or care whether or not you have the capacity to learn. I found that in order for me to be able to learn anything, however, I had to take information from the last moment and apply it to the present moment. When my left hemisphere was completely nonfunctional early on, it was impossible for me to learn, which was okay with me, but I am sure it was frustrating for those around me. A simple example of this was trying to put on my shoes and socks. I eventually became physically capable of putting my shoes and socks on, but I had no ability to understand why I would have to put my socks on before my shoes. To me they were simply independent actions that were not related and I did not have the cognitive ability to figure out the appropriate sequencing of the events. Over time, I regained the ability to weave moments back together to create an expanse of time, and with this ability came the ability to learn methodically again. Life in La-la land will always be just a thought away, but I am truly grateful for the ability to think with linearity once again.

Amazon.com: What can we learn about our brains and ourselves from your experience, even if we haven't lived through the kind of brain trauma you have?

Taylor: I learned that I have much more say about what goes on between my ears than I was ever taught and I believe that this is true for all of us. I used to understand that I had the ability to stop thinking about one thing by consciously choosing to preoccupy my mind with thinking about something else. But I had no idea that it only took 90 seconds for me to have an emotional circuit triggered, flush a physiological response through my body and then flush completely out of me. We can all learn that we can take full responsibility for what thoughts we are thinking and what emotional circuitry we are feeling. Knowing this and acting on this can lead us into feeling a wonderful sense of well-being and peacefulness.

Amazon.com: You are the "Singin' Scientist" for Harvard's Brain Bank (just as you were before your stroke). Could you tell us about the Brain Bank (in song or not)?

Taylor: There is a long-term shortage of brain tissue donated for research into the severe mental illnesses. Most people don't realize that when you sign the back of your license as an organ donor, the brain is not included. If you would like to donate your brain for research, you must contact a brain bank directly. There is also a shortage of "normal control" tissue for research. The bottom line reality is that if there were more tissue available for research, then more scientists would be dedicating their careers to the study of the severe mental illnesses and we would have more answers about what is going on with these disorders. The numbers of mentally ill individuals in our society are staggering. The most serious and disabling conditions affect about 6 percent--or one in 17--adults and 9-13 percent of children in the United States. Half of all lifetime conditions of mental illness start by age 14 years, and three-fourths by age 24 years.

For more information about brain donation to the Harvard brain bank, please call 1-800-BRAINBANK or visit them at: www.brainbank.mclean.org

If you would like to hear me sing the brain bank jingle, please visit www.drjilltaylor.com!

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What happens when something is sucked into a black hole? Does it disappear? Three decades ago, a young physicist named Stephen Hawking claimed it did-and in doing so put at risk everything we know about physics and the fundamental laws of the universe. Most scientists didn't recognize the import of Hawking's claims, but Leonard Susskind and Gerard t'Hooft realized the threat, and responded with a counterattack that changed the course of physics. THE BLACK HOLE WAR is the thrilling story of their united effort to reconcile Hawking's revolutionary theories of black holes with their own sense of reality-effort that would eventually result in Hawking admitting he was wrong, paying up, and Susskind and t'Hooft realizing that our world is a hologram projected from the outer boundaries of space.
A brilliant book about modern physics, quantum mechanics, the fate of stars and the deep mysteries of black holes, Leonard Susskind's account of the Black Hole War is mind-bending and exhilarating reading..
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In sumptuous and illuminating detail, Simon Winchester, the bestselling author of The Professor and the Madman ("Elegant and scrupulous"—New York Times Book Review) and Krakatoa ("A mesmerizing page-turner"—Time) brings to life the extraordinary story of Joseph Needham, the brilliant Cambridge scientist who unlocked the most closely held secrets of China, long the world's most technologically advanced country.

No cloistered don, this tall, married Englishman was a freethinking intellectual, who practiced nudism and was devoted to a quirky brand of folk dancing. In 1937, while working as a biochemist at Cambridge University, he instantly fell in love with a visiting Chinese student, with whom he began a lifelong affair.

He soon became fascinated with China, and his mistress swiftly persuaded the ever-enthusiastic Needham to travel to her home country, where he embarked on a series of extraordinary expeditions to the farthest frontiers of this ancient empire. He searched everywhere for evidence to bolster his conviction that the Chinese were responsible for hundreds of mankind's most familiar innovations—including printing, the compass, explosives, suspension bridges, even toilet paper—often centuries before the rest of the world. His thrilling and dangerous journeys, vividly recreated by Winchester, took him across war-torn China to far-flung outposts, consolidating his deep admiration for the Chinese people.

After the war, Needham was determined to tell the world what he had discovered, and began writing his majestic Science and Civilisation in China, describing the country's long and astonishing history of invention and technology. By the time he died, he had produced, essentially single-handedly, seventeen immense volumes, marking him as the greatest one-man encyclopedist ever.

Both epic and intimate, The Man Who Loved China tells the sweeping story of China through Needham's remarkable life. Here is an unforgettable tale of what makes men, nations, and, indeed, mankind itself great—related by one of the world's inimitable storytellers.

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Frankenstein, loved by many decades of readers and praised by such eminent literary critics as Harold Bloom, seems hardly to need a recommendation If you haven't read it recently, though, you may not remember the sweeping force of the prose, the grotesque, surreal imagery, and the multilayered doppelgänger themes of Mary Shelley's masterpiece. As fantasy writer Jane Yolen writes of this (the reviewer's favorite) edition, "The strong black and whites of the main text [illustrations] are dark and brooding, with unremitting shadows and stark contrasts. But the central conversation with the monster--who owes nothing to the overused movie image … but is rather the novel's charnel-house composite--is where [Barry] Moser's illustrations show their greatest power ... The viewer can all but smell the powerful stench of the monster's breath as its words spill out across the page. Strong book-making for one of the world's strongest and most remarkable books." Includes an illuminating afterword by Joyce Carol Oates..
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Edited by Maurice Hindle..
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As a scientist, Albert Einstein is undoubtedly the most epic among 20th-century thinkers. Albert Einstein as a man, however, has been a much harder portrait to paint, and what we know of him as a husband, father, and friend is fragmentary at best. With Einstein: His Life and Universe, Walter Isaacson (author of the bestselling biographies Benjamin Franklin and Kissinger) brings Einstein's experience of life, love, and intellectual discovery into brilliant focus. The book is the first biography to tackle Einstein's enormous volume of personal correspondence that heretofore had been sealed from the public, and it's hard to imagine another book that could do such a richly textured and complicated life as Einstein's the same thoughtful justice. Isaacson is a master of the form and this latest opus is at once arresting and wonderfully revelatory. --Anne Bartholomew

Read "The Light-Beam Rider," the first chapter of Walter Isaacson's Einstein: His Life and Universe.

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Five Questions for Walter Isaacson

Amazon.com: What kind of scientific education did you have to give yourself to be able to understand and explain Einstein's ideas?

Isaacson: I've always loved science, and I had a group of great physicists--such as Brian Greene, Lawrence Krauss, and Murray Gell-Mann--who tutored me, helped me learn the physics, and checked various versions of my book. I also learned the tensor calculus underlying general relativity, but tried to avoid spending too much time on it in the book. I wanted to capture the imaginative beauty of Einstein's scientific leaps, but I hope folks who want to delve more deeply into the science will read Einstein books by such scientists as Abraham Pais, Jeremy Bernstein, Brian Greene, and others.

Amazon.com: That Einstein was a clerk in the Swiss Patent Office when he revolutionized our understanding of the physical world has often been treated as ironic or even absurd. But you argue that in many ways his time there fostered his discoveries. Could you explain?

Isaacson: I think he was lucky to be at the patent office rather than serving as an acolyte in the academy trying to please senior professors and teach the conventional wisdom. As a patent examiner, he got to visualize the physical realities underlying scientific concepts. He had a boss who told him to question every premise and assumption. And as Peter Galison shows in Einstein's Clocks, Poincare's Maps, many of the patent applications involved synchronizing clocks using signals that traveled at the speed of light. So with his office-mate Michele Besso as a sounding board, he was primed to make the leap to special relativity.

Amazon.com: That time in the patent office makes him sound far more like a practical scientist and tinkerer than the usual image of the wild-haired professor, and more like your previous biographical subject, the multitalented but eminently earthly Benjamin Franklin. Did you see connections between them?

Isaacson: I like writing about creativity, and that's what Franklin and Einstein shared. They also had great curiosity and imagination. But Franklin was a more practical man who was not very theoretical, and Einstein was the opposite in that regard.

Amazon.com: Of the many legends that have accumulated around Einstein, what did you find to be least true? Most true?

Isaacson: The least true legend is that he failed math as a schoolboy. He was actually great in math, because he could visualize equations. He knew they were nature's brushstrokes for painting her wonders. For example, he could look at Maxwell's equations and marvel at what it would be like to ride alongside a light wave, and he could look at Max Planck's equations about radiation and realize that Planck's constant meant that light was a particle as well as a wave. The most true legend is how rebellious and defiant of authority he was. You see it in his politics, his personal life, and his science.

Amazon.com: At Time and CNN and the Aspen Institute, you've worked with many of the leading thinkers and leaders of the day. Now that you've had the chance to get to know Einstein so well, did he remind you of anyone from our day who shares at least some of his remarkable qualities?

Isaacson: There are many creative scientists, most notably Stephen Hawking, who wrote the essay on Einstein as "Person of the Century" when I was editor of Time. In the world of technology, Steve Jobs has the same creative imagination and ability to think differently that distinguished Einstein, and Bill Gates has the same intellectual intensity. I wish I knew politicians who had the creativity and human instincts of Einstein, or for that matter the wise feel for our common values of Benjamin Franklin.

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More to Explore

Benjamin Franklin: An American Life

Kissinger: A Biography

The Wise Men: Six Friends and the World They Made

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Dr. Francis Collins, head of the Human Genome Project, is one of the world's leading scientists. He works at the cutting edge of the study of DNA, the code of life. Yet he is also a man of unshakable faith in God and scripture.

Dr. Collins believes that faith in God and faith in science can coexist within a person and be harmonious. In The Language of God he makes his case for God and for science. He has heard every argument against faith from scientists, and he can refute them. He has also heard the needless rejection of scientific truths by some people of faith, and he can counter that, too. He explains his own journey from atheism to faith, and then takes readers for a stunning tour of modern science to show that physics, chemistry, and biology can all fit together with belief in God and the Bible. The Language of God is essential reading for anyone who wonders about the deepest questions of faith: Why are we here? How did we get here? What does life mean?.
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