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Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA
Molecular biologist Elizabeth Blackburn—one of Time magazine’s 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. In this compelling biography, Catherine Brady tells the story of Elizabeth Blackburn's life and work and the emergence of a new field of scientific research on the specialized ends of chromosomes and the telomerase enzyme that extends them. In the early stages of telomere research, telomerase, heralded as a potential cure for cancer and diseases related to aging, attracted the voracious interest of biotech companies. The surrounding hype succeeded in confusing the role of telemorase in extending the life of a cell with a mechanism that might extend the lifespan of an entire organism. In Brady's hands, Blackburn's story reveals much about the tension between pure and applied science, the politicking that makes research science such a competitive field, and the resourceful opportunism that characterizes the best scientific thinking. Brady describes the science accessibly and compellingly. She explores Blackburn's struggle to break down barriers in an elite, male-dominated profession, her role as a mentor to other women scientists (many of whom have made their mark in telomere research), and the collaborative nature of scientific work. This book gives us a vivid portrait of an exceptional woman and a new understanding of the combination of curiosity, imaginative speculation, and aesthetic delight that powers scientific discovery..
Price: $15.40
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Lenin's Embalmers
Professor Ilya Zbarski mummified Lenin two months after his death to maintain the Soviet founder's body in perpetuity Between 1924 and the fall of communism in 1991, hundreds of millions of visitors paid their respects to the embalmed bodies of Lenin and later, Stalin. This text reveals the story of Zbarski, his family and of those who worked in the mausoleum laboratory. Lenin's body was plunged into a secret solution based on glycerine and potassium acetate. This story, unthinkable except in a totalitarian regime, is also that of the burgeoning Soviet Union and those who, disregarding Stalin and his growing antisemitic paranoia, believed that working in the shadows of the mausoleum would protect them forever. Abandoned by the State since 1991, the laboratory can only survive through the patronage of the "nouveaux riches" and the Russian mafia dynasties. The text includes both archival and contemporary photographs..
Price: $106.14
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Candid Science II: Conversations with Famous Biomedical Scientists
This invaluable book contains 36 interviews, including 26 with Nobel laureates It presents a cross-section of biomedical science, a field that has been dominant in science for the past half century. The in-depth conversations cover important research areas and discoveries, as well as the roads to these discoveries, including aspects of the scientists' work that never saw publication. They also bring out the humanness of the famous scientists - the reader learns about their backgrounds, aspirations, failings, and triumphs. The book is illustrated with snapshots of the conversations and photos provided by the interviewees. It is a follow-up to the critically acclaimed Candid Science: Conversations with Famous Chemists, by the same author..
Price: $38.00
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Linus Pauling: And the Chemistry of Life (Oxford Portraits in Science)
Linus Pauling was the most important chemist, and arguably the most important American scientist, of the 20th century From his description of the chemical bond to his discovery of the cause of sickle-cell anemia and his groundbreaking work with vitamin C, his work stretched the boundaries of chemistry, physics, biology, immunology, and more. Acclaimed science writer Tom Hager brings Pauling's wide range of scientific accomplishments vividly to life while also shedding light on Pauling's activities outside the scientific realm. He shows how Pauling used his popularity to advance political causes, particularly his opposition to the spread of nuclear weapons during the 1950s. Despite the troubles his political activism caused him, he remained unmoved in his dedication to making the world a safer place. His perseverance was rewarded with a Nobel Peace Prize in 1963, which along with his 1954 Nobel Prize in Chemistry, made him the only person in history to win two unshared Nobels..
Price: $22.39
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For the Love of Enzymes: The Odyssey of a Biochemist
In 1645 the Japanese samurai Musashi Miamoto wrote A Book of Five Rings, which described the attitudes necessary for individual success. Though he was a swordsman, his book was not limited to combat but addressed the much broader question of how to achieve excellence in life through study, discipline, and planning. It is still avidly read in Japan today. Arthur Kornberg's book is a modern-day Book of Five Rings that replaces the medium of swordsmanship with that of biochemistry, particularly enzymology. As Kornberg describes his successive research problems, the challenges they presented, and the ultimate accomplishments that resulted, he provides us with a primer in the strategies needed to do scientific work of great significance. Moreover, these strategies are played out in the context of solving some of the great biochemical problems of the twentieth century. The ability to manipulate and alter DNA fired a revolution that forever changed the nature of biology. Arthur Kornberg is a primary architect of that revolution, arguably one of the two or three most important biologists of this time. Prior to Kornberg, genetic information and later DNA were imbued by biologists with an almost vitalistic aura. Kornberg demonstrated that DNA is a molecule synthesized by enzymes, like all other chemical constituents of the cell. More important, he trained a school of scientists who focused on and discovered many of the enzymatic activities that act on DNA. It is these enzymes in particular that allow modern "genetic engineering." For the Love of Enzymes does not describe a single lucky or hard-won accomplishment. Rather, it is the story of thirty years of decisive campaigns, nearly all of which led to insights of major significance. In relating his story, Kornberg never avoids the difficult question of "why": why he felt classical nutritional studies had reached a plateau, why he turned to enzymology as a discipline in which the important answers would be found, and why he believes the study of enzymes will grow ever more important as we face the new scientific frontier of brain function. This book will challenge students of biology and chemistry at all levels who want to do important work rather than simply follow popular trends. It will also delight and inform readers who wish to understand how "real" science is done, and to learn of the values that guide one of our greatest researchers. .
Price: $78.90
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Basic Mathematics for Biochemists
Mathematics is essential to the study and understanding of biochemistry yet most undergraduates do not have a grasp of maths. This book sets out all the mathematics needed for an undergraduate course in biochemistry, assuming a minimum of prior knowledge. Emphasis is placed on topics necessary for biochemists and all the examples are relevant to biochemistry. Each chapter contains illustrative boxes and worked examples and also a problem section (the answers are given in the back of the book). The book starts by covering the basic concepts of mathematics such as manipulating fractions, functions, and plotting graphs and then explains exponents and logarithms in depth. The next two chapters cover all the ordinary differentiation and integration required by the biochemist. Partial differentiation is explained in a later chapter. Chapter 6 is about solving equations (linear, simultaneous, quadratic, and higher-order) and the final chapter covers the basic ideas of statistics. Basic Mathematics for Biochemists will therefore be invaluable to all biochemistry undergraduates and will also be useful to more experienced biochemists needing to refresh their maths..
Price: $47.23
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Biochemists' Song Book
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Mass Spectrometry for Chemists and Biochemists
This book describes the full range of techniques and applications used in mass spectrometry Researchers in universities and industry laboratories use this versatile technique because of its ability to identify a minute amount of material quickly. The technique solves analytical problems in a huge variety of fields. The authors adopt an instructional approach and make use of recent examples to illustrate important points. This second edition includes new methods and applications that have developed in the past ten years. The authors discuss powerful methods combining mass spectrometry with newer separation techniques, the increased use of computers, and analysis of once difficult polar and large-mass compounds such as proteins using new ionization methods. The book, requiring no previous knowledge of mass spectrometry, is an ideal teaching text at both the undergraduate and postgraduate level, and will also be of considerable interest to research workers..
Price: $83.93
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Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists
A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved..
Price: $29.99
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